Glutathione is a potent antioxidant naturally produced in the body that supports cellular protection, skin health, and detoxification processes. Administered via intramuscular (IM) injection or intravenous (IV) infusion, this therapy aims to enhance systemic benefits, such as reducing oxidative stress and promoting skin brightening. Below is an overview of our protocol, presented in clear and accessible terms.
Pre-Administration Guidelines
Informed consent: We require written agreement after discussing potential benefits (e.g., antioxidant support and skin lightening), risks (e.g., nausea or allergic reactions), and any off-label applications.
Initial evaluation: Assess vital signs, review medical history, screen for allergies, and check for contraindications, including conditions like asthma, pregnancy, or kidney impairment.
Laboratory tests if warranted: May include complete blood count (CBC), liver and kidney function panels, and glucose-6-phosphate dehydrogenase (G6PD) enzyme testing to exclude risks of hemolysis.
Medication Details
Dosage: 600–1,200 mg per session, starting at 600 mg to evaluate tolerance. Prepared from a 200 mg/mL vial, using 3–6 mL diluted in 10–20 mL of 0.9% normal saline for IV push, or 100 mL for infusion if preferred.
Administration route: IV is recommended for optimal systemic absorption; IM serves as a convenient alternative.
Administration Protocol
Method and timing: Deliver as a slow IV push over 10–15 minutes or as an infusion over 30–60 minutes to reduce potential irritation. For IM, administer as a rapid injection lasting 1–2 minutes.
Schedule: 1–3 sessions per week, typically 2–3 times weekly for the initial 4 weeks, followed by weekly maintenance.
Treatment duration: Loading phase of 4–8 weeks, with ongoing sessions as required. Re-evaluate progress every 4 weeks.
Side Effects and Management
Side effects are generally mild and temporary, often related to the dosage or administration speed.
Common Side Effects
These may include nausea, headache, dizziness, abdominal discomfort, bloating, or mild anxiety. Management involves slowing the infusion rate and ensuring adequate hydration.
Less frequently observed: Allergic reactions such as rash, hives, swelling, or respiratory difficulty; potential blood cell issues in susceptible individuals; or local reactions like bruising or swelling at the injection site.
Management Strategies
For severe symptoms, immediately discontinue administration and provide supportive care, such as antihistamines or oxygen if needed. Continuous monitoring and documentation are standard.
Prevention Measures
To minimize risks, we employ gradual dosing, pre-treatment hydration, and individualized adjustments. All patients are screened for contraindications prior to starting therapy.
